Recurrent atrial fibrillation pulmonary vein goat Causes of rapid excited

 Key words Atrial fibrillation; pulmonary vein; electrophysiology; goat
Abstract Objective atrial fibrillation (AF) of local goat model of recurrent pulmonary vein quickly excited (repetitive rapid activations, RRA) of the formation mechanism. Methods
8 goats The left atrium (LA) free wall and the left superior pulmonary vein adventitia (LSPV) root suture electrodes, stimulation of atrial fibrillation using a self released in vitro stimulation of 50 Hz atrial impulses to stimulate the period 1
s, at intervals of 2 s, in (9. 3 + / -4. 6) d (6 ~ 16) d induced from within the hair for more than 24 h to maintain the continuity of atrial fibrillation. Analysis of sinus rhythm and pacing the left atrial pulmonary vein potential
PVP features and the continuing process of atrial fibrillation in the RRA. Results in sinus rhythm (PVP) is not obvious, the left atrial stimulation showed PVP, with the basic cycle length shortened
, LA2PVP the spacing to increase, PVP split between, and can induce atrial fibrillation. fibrillation pulmonary vein just attack electrogram morphology, consistent with rapid atrial stimulation. In atrial fibrillation when the newly induced
, pulmonary vein can be a brief local RRA, but the proportion of AF time low, at 3.3% + / -4. 0%. With the stimulation time / extension of the duration of atrial fibrillation,
RRA gradually increase the proportion of ; after 24 h in the continuous AF, the duration of pulmonary vein RRA total activation time of 91. 8% + / -6. 7% (P <0. 05). Conclusion
RRA in this model the generation of the pulmonary veins its complex structure, but not with increased local self-regulation and trigger excitement has nothing to do. fibrillation during the gradual stabilization, RRA increase in the proportion with atrial
/ pulmonary vein electrical remodeling progression.
of persistent atrial atrial fibrillation model study found that in canine pulmonary vein mapping can be quickly moved to the focal repetitive (repetitive rapid activation, RRA
), radiofrequency ablation of atrial fibrillation in the partial termination can only induce a short array atrial fibrillation. tips, including pulmonary vein in the chest, including large veins of the local fast excited again, in the maintenance of persistent AF dogs play an important role. However, in previous studies
, only sustained atrial fibrillation after pulmonary vein Mapping excited to find that RRA, its generation mechanism is not very clear. In this study, using goat AF model, the occurrence of pulmonary vein RRA, the law of development for analysis ......